PTPN 1 ( protein tyrosine phosphatase , non - receptor type 1 )
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Angiopoietin-1 Regulates Brain Endothelial Permeability through PTPN-2 Mediated Tyrosine Dephosphorylation of Occludin
OBJECTIVE Blood brain barrier (BBB) breakdown and increased endothelial permeability is a hallmark of neuro-vascular inflammation. Angiopoietin-1 (Ang-1), a Tie-2 receptor agonist ligand, is known to modulate barrier function of endothelial cells; however the molecular mechanisms related to Ang-1 mediated repair of Tight Junctions (TJs) in brain endothelium still remain elusive. In this study, ...
متن کاملAtlas of Genetics and Cytogenetics in Oncology and Haematology PTPN 6 ( protein tyrosine phosphatase , non - receptor type 6 )
The human PTPN6 gene is divided in 17 exons spanning a length of 14740 bp. A notable feature of the PTPN6 gene is that it has two promoter regions. Whereas the distal promoter, P1, located upstream of the very short exon 1 (also known as exon 1a) is active in epithelial cells, the proximal promoter P2 that initiates gene transcription from exon 2 (known as exon 1b), is utilized by the hematopoi...
متن کاملTherapeutic Targets of Type 2 Diabetes: an Overview
Submit Manuscript | http://medcraveonline.com Abbreviations: T1D: Type 1 diabetes; T2D: Type 2 diabetes; NIDDM: Non-Insulin-Dependent Diabetes Mellitus; TNF-α: Tumor Necrosis Factor Alpha; IRS: Insulin Receptor and Substrates; RXR: Retinoid X-Receptor; PTP1B: Protein Tyrosine Phosphatase 1B; PTPs: Protein Tyrosine Phosphatases; GPR: G-Protein Coupled Receptor; LA: Lipoic Acid; NAC: N-Acetyl-l-C...
متن کاملAn Integrated Computational Approach for Plant-Based Protein Tyrosine Phosphatase Non-Receptor Type 1 Inhibitors
BACKGROUND Protein tyrosine phosphatase non-receptor type 1 is a therapeutic target for the type 2 diabetes mellitus. According to the International Diabetes Federation 2015 report, one out of 11 adults suffers from diabetes mellitus globally. OBJECTIVE Current anti-diabetic drugs can cause life-threatening side-effects. The present study proposes a pipeline for the development of effective a...
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